Mycobacteria‐induced granuloma necrosis depends on IRF‐1
نویسندگان
چکیده
منابع مشابه
The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis.
A central tenet of tuberculosis pathogenesis is that caseous necrosis leads to extracellular matrix destruction and bacterial transmission. We reconsider the underlying mechanism of tuberculosis pathology and demonstrate that collagen destruction may be a critical initial event, causing caseous necrosis as opposed to resulting from it. In human tuberculosis granulomas, regions of extracellular ...
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The infection of tumor necrosis factor (TNF)-deficient mice with low doses of the virulent Mycobacterium avium strain 25291 led to the appearance of necrotic granulomas at 93 days of infection, i.e., sooner than necrotic granulomas appeared in C57BL/6 animals. Additionally, TNF-deficient mice exhibited higher mycobacterial loads in the infected organs, had extremely exacerbated gamma interferon...
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a distinct condition, affects the lymphatic glands of the groin, is sometimes associated with constitutional symptoms, and is now believed to be due to a filterable virus, the infection being of genital origin. Inguinal granuloma is a separate entity with no constitutional features, the lesion being a granulomatous ulcer about the genitalia or the skin in the neighbourhood. The condition is met...
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Oncogenic activation of Ras/MEK downregulates the expression of interferon regulatory factor 1 (IRF1), which is a prerequisite for oncolytic viruses to replicate in cancer cells [1]. Moreover, restoration of IRF1 expression is essential to induce apoptosis of cancer cells treated with a MEK inhibitor [2]. However, the molecular mechanisms that underlie IRF1 downregulation by Ras/MEK remain uncl...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2008
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2008.00470.x